五本木クリニック・ロゴマーク
Dr.Yoshiyuki AKIYAMA

秋山 佳之（あきやま よしゆき）

当院の間質性膀胱炎専門外来担当医

秋山医師は結婚前から当院で働いてくれていました。

結婚式に招かれて泌尿器科では高名な医師ばかりの上座テーブルに私ごときが座らせてもらいました。初心貫徹で排尿障害に力をいれて、知見を広めるために海外留学を数年前にした後も当院で働いてくれています。

排尿障害のガイドライン筆者の上から二番目に秋山医師の名前を見つけた時以来、私はついつい敬語を使ってしまいます。

院長・桑満おさむ

　

秋山佳之医師・泌尿器科医

資格・所属学会

■医学博士 ■日本泌尿器科学会・日本専門医機構　泌尿器科専門医・指導医 ■日本泌尿器内視鏡・ロボティクス学会 腹腔鏡技術認定医・ロボット支援手術プロクター（前立腺・膀胱、腎・副腎）　■日本内視鏡外科学会 技術認定医（泌尿器腹腔鏡）■日本がん治療認定医機構がん治療認定医　■日本排尿機能学会 専門医　■難病指定医　■身体障害者福祉法指定医　■仙骨神経刺激療法講習 修了　■緩和ケア研修会 修了　■厚生労働省難治性疾患政策研究事業 班員　■間質性膀胱炎・膀胱痛症候群診療ガイドライン作成委員　■東アジア間質性膀胱炎診療ガイドライン作成委員　■国際間質性膀胱炎研究会（ESSIC）ガイドライン作成委員

受賞歴

  1. Delegates choice Award for open discussion posters: Pain and Sexual dysfunction
    「A prospective randomized control trial of botulinum toxin A (Botox A) injection for interstitial cystitis」 44th International Continence Society (ICS) annual meeting. 2014 Oct. Rio de Janeiro. Brazil
  2. Best Basic Science Abstract Award
    「Inflammatory infiltrates specific to Hunner type interstitial cystitis」 46th International Continence Society (ICS) annual meeting. 2016 Sep. Tokyo. Japan
  3. 第23回日本排尿機能学会：河邉賞
  4. 第16回Asahi Kasei Pharma Urological Academy研究助成：優秀テーマ
  5. 第26回泌尿器科分子・細胞研究会：研究奨励賞（口演部門）
  6. 第105回日本泌尿器科学会総会：総会賞
  7. 第106回日本泌尿器科学会総会：総会賞
  8. Best Abstract Award (Second Prize for the Best Abstract in Non-Oncology)
    35th Annual EAU Congress of the European Association of Urology. 2020, Mar. Amsterdam, Netherland
  9. BEST IN CATEGORY PRIZE (BEST BASIC SCIENCE)
    50th International Continence Society (ICS) annual meeting. 2020 Nov. Las Vegas, NV, United States.
  10. Best Reviewer Award for 2020, Lower Urinary Tract Symptoms
  11. 第109回日本泌尿器科学会総会（2021, Dec、横浜市）　総会賞
  12. IJU Most Cited Article Award of the Year 2021
  13. 第110回日本泌尿器科学会総会（2023, April, 神戸市） International Session Award

英語論文

  1. Akiyama Y*, Niimi A, Nomiya A, Taguchi S, Yamada Y, Sato Y, Kawai T, Yamada D, Kume H, Homma Y. Efficacy and safety of intravesical dimethyl sulfoxide treatment for patients with refractory Hunner-type interstitial cystitis: real-world data post-official approval in Japan. Int J Urol. 2023. [Online ahead of print] PMID: 37817647
  2. Akiyama Y*, Harada K, Miyakawa J, Kreder KJ, O’Donnell MA, Maeda D, Katoh H, Hori M*, Owari K, Futami K, Ishikawa S, Ushiku T, Kume H, Homma Y, and Luo Y*. Th1/17 polarization and potential treatment by an anti-interferon-γ DNA aptamer in Hunner-type interstitial cystitis. iScience. 2023. [Online ahead of print]
  3. Akiyama Y*, Niimi A, Nomiya A, Taguchi S, Yamada Y, Sato Y, Yamada D, Maeda D, Ushiku T, Kume H, Homma Y. Efficacy and safety of low-dose oral prednisolone for patients with refractory Hunner-type interstitial cystitis. Eur Urol Open Sci. 2023; 56: 1-8. PMID: 37822513
  4. Akiyama Y, Sonehara K, Maeda D, Katoh H, Naito T, Yamamoto K, Biobank Japan Project, Morisaki T, Ishikawa S, Ushiku T, Kume H, Homma Y, Okada Y. Genome-wide association analysis identifies susceptibility loci within the major histocompatibility complex region for Hunner-type interstitial cystitis. Cell Rep Med. 2023; 4: 101114. PMID: 37467720
  5. Kurano M, Sumitani M, Akiyama Y, Yamada M, Fujimura D, Yamaki S, Kano K, Aoki J, Hayakawa K, Takahashi T, Hirai T, Okawa A, Kume H, Ogata T, Tanaka S, Chikuda H, Yatomi Y. Usefulness of lysophosphatidylcholine measurement in the cerebrospinal fluid for differential diagnosis of neuropathic pain : possible introduction into clinical laboratory testing. Clini Chim Acta. 2023; 541: 117249. PMID: 36764506
  6. Iwaki T, Akiyama Y*, Nosato H, Kinjo M, Niimi A, Taguchi S, Yamada Y, Sato Y, Kawai T, Yamada D, Sakanashi H, Kume H, Homma Y, Fukuhara H. Deep learning models for cystoscopic recognition of Hunner lesion in interstitial cystitis. Eur Urol Open Sci. 2023; 49: 44-50.
  7. Nakamura M, Yamada Y, Sato Y, Honda K, Yamada D, Kawai T, Akiyama Y, Suzuki M, Kume H. Preservation of pelvic floor muscles contributes to early continence recovery after robot-assisted radical prostatectomy. PLoS One. 2022; 17: e0275792.
  8. Akiyama Y*, Miyakawa J, O’Donnell MA, Kreder KJ, Luo Yi, Maeda D, Ushiku T, Kume H, Homma Y. Reply by Authors. J Urol. 2022; 207: 646.
  9. Akiyama* Y. Biomarkers in Interstitial Cystitis/Bladder Pain Syndrome with and without Hunner Lesion: A Review and Future Perspectives. Diagnostics (Basel). 2021; 11: 2238.
  10. Akiyama Y*, Niimi A, Igawa Y, Nomiya A, Yamada Y, Sato Y, Kawai T, Yamada D, Kume H, Homma Y. Cystectomy for patients with Hunner type interstitial cystitis at a tertiary referral center in Japan. Low Urin Tract Symptoms. 2022; 14: 102-108.
  11. Akiyama Y*, Miyakawa J, O’Donnell MA, Kreder KJ, Luo Yi, Maeda D, Ushiku T, Kume H, Homma Y. Overexpression of HIF1α in Hunner Lesions of Interstitial Cystitis: Pathophysiological Implications. J Urol. 2022; 207: 635-646.
  12. Akiyama Y. Editorial Comment from Dr Akiyama to Decreased urothelial cytoskeleton and cell proliferation protein expression suggest interstitial cystitis/bladder pain syndrome patients with Hunner’s lesion and grade 3 glomerulation might be different from other types of patients. Int J Urol. 2021; 28: 831.
  13. Yoshimura N, Homma Y, Tomoe H, Otsuka A, Kitta T, Masumori N, Akiyama Y, Niimi A, Mitsui T, Nanri M, Namima T, Takei M, Yamaguchi A, Sekiguchi Y, Kajiwara M, Kobayashi S, Ameda K, Ohashi Y, Sakamoto S, Muraki O, Shishido T, Kageyama S, Kokura K, Okazoe H, Yamanishi T, Watanabe T, Uno T, Ohinata A, Ueda T. Efficacy and safety of intravesical instillation of KRP-116D (50% dimethyl sulfoxide solution) for interstitial cystitis/bladder pain syndrome in Japanese patients: A multicenter, randomized, double-blind, placebo-controlled, clinical study. Int J Urol. 2021; 28: 545-553.
  14. Akiyama　Y*, Zaitsu M, Watanabe D, Yoshimura I, Niimi A, Nomiya A, Yamada Y, Sato Y, Nakamura M, Kawai T, Yamada D, Suzuki M, Kume H, Homma Y. Relationship between the frequency of electrocautery of Hunner lesions and changes in bladder capacity in patients with Hunner type interstitial cystitis. Scientific Reports. 2021; 11: 105.
  15. Akiyama Y*, Yao JR, Kreder KJ, O’Donnell MA, Lutgendorf SK, Lyu D, Maeda D, Kume H, Homma Y, and Luo Y*. Autoimmunity to urothelial antigen causes bladder inflammation, pelvic pain and voiding dysfunction: a novel animal model for Hunner type interstitial cystitis. American Journal of Physiology-Renal Physiology (Am J Physiol Renal Physiol). 2021; 320: F174-F182.
  16. Watanabe D, Akiyama Y*, Niimi A, Nomiya A, Yamada Y, Sato Y, Nakamura M, Kawai T, Yamada D, Suzuki M, Igawa Y, Kume H, Homma Y. Clinical characterization of interstitial cystitis/bladder pain syndrome in women based on the presence or absence of Hunner lesions and glomerulations. Low Urin Tract Symptoms. 2020; 13: 139-143. Top Cited Article 2021-2022 in Lower Urinary Tract Symptoms.
  17. Akiyama Y* and Homma Y. Immunomodulating therapies for interstitial cystitis/bladder pain syndrome. Curr Bladder Dysfunct Rep. 2020; 15 :186-191.
  18. Homma Y, Akiyama Y, Tomoe H, Furuta A, Ueda T, Maeda D, Lin AT, Kuo HC, Lee MH, Oh SJ, Kim JC, Lee KS. Clinical guidelines for interstitial cystitis/bladder pain syndrome. Int J Urol. 2020; 27: 578-589.
    Top Downloaded Article 2019-2020 in International Journal of Urology
  19. Akiyama Y*, Luo Yi, Hanno PM, Maeda D, Homma Y. Interstitial cystitis/bladder pain syndrome: The Evolving Landscape, Animal Models, and Future Perspectives. Int J Urol. 2020; 27: 491-503.
    Top Cited Article 2020-2021 in International Journal of Urology
    Most Cited Article 2021-2022 in International Journal of Urology
  20. Akiyama Y*. Update on the pathophysiology of interstitial cystitis/bladder pain syndrome. Current Bladder Dysfunction Reports. 2020; 15: 1-8.
  21. Homma Y, Akiyama Y, Niimi A, Nomiya A, Igawa Y. Classification, Characterization, and Sub-Grouping of Interstitial Cystitis. Curr Bladder Dysfunct Rep. 2019; 14: 294-300.
  22. Akiyama Y*, Maeda D, Katoh H, Morikawa T, Niimi A, Nomiya A, Sato Y, Kawai T, Goto A, Fujimura T, Fukuhara H, Nakagawa T, Igawa Y, Ishikawa S, Fukayama M, Kume H, Homma Y. Molecular Taxonomy of Interstitial Cystitis/Bladder Pain Syndrome Based on Whole Transcriptome Profiling by Next-Generation RNA Sequencing of Bladder Mucosal Biopsies. J Urol. 2019; 202: 290-300.
  23. Akiyama Y *and Hanno P. Phenotyping of interstitial cystitis/bladder pain syndrome. Int J Urol. 2019; 26 (Suppl. 1): 17-19.
  24. Akiyama Y, Homma Y and Maeda D. Pathology and terminology of interstitial cystitis/bladder pain syndrome: A review. Histol Histopathol. 2019; 34: 25-32.
  25. Akiyama Y*, Niimi A, Nomiya A, Yamada Y, Nakagawa T, Fujimura T, Fukuhara H, Kume H, Igawa Y, and Homma Y. Extent of Hunner lesions: The relationships with symptom severity and clinical parameters in Hunner type interstitial cystitis patients. Neurourol Urodyn. 2018; 37: 1441-1447.
  26. Akiyama Y, Maeda D, Morikawa T, Niimi A, Nomiya A, Yamada Y, Igawa Y, Goto A, Fukayama M and Homma Y. Digital Quantitative Analysis of Mast Cell Infiltration in Interstitial Cystitis. Neurourol Urodyn. 2018; 37: 650-657.
  27. Niimi A, Igawa Y, Aizawa N, Honma T, Nomiya A, Akiyama Y, Kamei J, Fujimura T, Fukuhara H, Homma Y. Diagnostic value of urinary CXCL10 as a biomarker for predicting Hunner type interstitial cystitis. Neurourol Urodyn. 2018; 37: 1113-1119.
  28. Ichihara K, Aizawa N, Akiyama Y, Kamei J, Masumori N, Andersson KE, Homma Y, Igawa Y. Toll-like receptor 7 is overexpressed in the bladder of Hunner type interstitial cystitis and its activation in the mouse bladder can induce cystitis and bladder pain. Pain. 2017; 158: 1538-1545.
  29. Akiyama Y*, Morikawa T, Maeda D, Shintani Y, Niimi A, Nomiya A, Nakayama A, Igawa Y, Fukayama M, Homma Y. Increased CXCR3 Expression of Infiltrating Plasma Cells in Hunner Type Interstitial Cystitis. Sci Rep. 2016; 6: 28652.
  30. Maeda D*, Akiyama Y*, Morikawa T, Kunita A, Ota Y, Katoh H, Niimi A, Nomiya A, Ishikawa S, Goto A, Igawa Y, Fukayama M, Homma Y. Hunner-Type (Classic) Interstitial Cystitis: A Distinct Inflammatory Disorder Characterized by Pancystitis, with Frequent Expansion of Clonal B-Cells and Epithelial Denudation. PLoS One. 2015; 10: e0143316. (Top 10% most cited PLOS ONE paper published in 2015.)
  31. Akiyama Y, Nomiya A, Niimi A, Yamada Y, Fujimura T, Nakagawa T, Fukuhara H, Kume H, Igawa Y, Homma Y. Botulinum toxin type A injection for refractory interstitial cystitis: A randomized comparative study and predictors of treatment response. Int J Urol. 2015;22(9):835-41.

秋山佳之医師は
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